Don't Count Elderly Patients Out as FMT Donors
FEBRUARY 22, 2017
Changes to overall microbial diversity in older, healthy fecal microbiota transplant (FMT) donors don’t appear to affect the clinical efficacy of the procedure.
Researchers from Johns Hopkins University observed 28 healthy FMT donors 20 to 82 years to investigate the effects of age of healthy donors on their fecal microbiota. The researchers wanted to examine the impact of these changes on the clinical efficacy of FMT.
On the morning of the scheduled FMT (between January 2011 and October 2014), the donors submitted a stool sample for the respective recurrent Clostridium difficile (C. difficile) infection patients. The researchers split up the samples into groups based on the donors’ ages, older than or younger than 60 years.
The researchers reported that all the recurrent C. difficile infection patients had successful FMT procedures, resulting in negative C. difficile fecal test in four to 12 weeks following FMT. The researchers did not find any significant differences in the age of healthy donors and their respective patients in either age group.
Follow-up for each FMT recipient was at least 12 months, though many were followed for much longer. None of the patients had any recurrent C. difficile infection.
“The age gap between the donors and recipients in our study did not have any effect on the clinical outcome of FMT,” the study authors wrote. “Furthermore, the long-term follow-up indicated that there was no recurrence of C. difficile infection in either group over 12 months.”
The researchers determined that actinobacteria was significantly less abundant in the group of stool samples from donors older than 60 years compared to the levels from the donors less than 60 years.
Veillonellaceae abundance was also lower in donor samples from the over 60 group compared to the under 60 group. The presence of bifidobacteriaceae was also lower in the group aged over 60 compared to the group aged less than 60 years. Additionally, the investigators found that the bifidobacteriaceae diversity decreased with age: Bifidobacterium bifidum and Bifidobacterium adolescentis were less abundant in the greater than age 60 group compared to the less than age 60 years group.
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