The authors say that for uveitis “there is a large unmet medical need" for identifying other therapies. Adalimumab is associated with decreased visual impairment and decreased risk of uveitic flare, but more adverse events, according the results from a recent multinational phase 3 trial.
“These cases highlight a potential association between erlotinib therapy and bilateral, acute, simultaneous-onset anterior uveitis and suggest some patients may respond to topical corticosteroids, despite continued use of the drug.”
The treatment of various eye conditions can vary widely depending on where a patient lives. While some countries may have the best technology readily available others are lacking in not only equipment but training.
Retrospective study results indicate that golimumab may be a new and effective choice for maintaining remission and preventing recurrence of severe, recurrent anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis.
Adalimumab, infliximab, and etanercept, reduced the number of uveitis relapses in a retrospective, long-term study of uveitis patients with HLA-B27-positive ankylosing spondylitis who had taken one of these biological agents for at least 1 year.
A long-acting fluocinolone acetonide implant improved visual acuity and controlled intraocular inflammation for 2 years in 11 eyes of 11 patients with noninfectious intermediate uveitis, posterior uveitis, or panuveitis.