Robert Zivadinov: The TOPIC Study's Key Takeaways

NOVEMBER 27, 2017
Matt Hoffman
At MS Paris 2017, MD Magazine sat with experts and key opinion leaders in the treatment of multiple sclerosis (MS) to discuss the important and innovative topics from the conference. 

Robert Zivadinov, MD, is a professor of neurology at the University of Buffalo and was an author in the TOPIC study, which examined cortical gray matter atrophy in patients with MS. The study was conducted with 618 patients, exploring and comparing the effects of 7 mg and 14 mg teriflunomide to a placebo.

The results showed that teriflunomide significantly reduced the risk of relapse-defining, clinically definite MS with the 14 mg dose (hazard ratio [HR], 0.574; 95% CI, 0.379-0.869; = .0087) and at the 7 mg dose (HR, 0.628; 95% CI, 0.416-0.949; = .0271). The therapy also reduced the risk of relapse or the development of a new MRI lesion compared with placebo at the 14 mg dose (HR, 0.651; 95% CI, 0.515-0.822; = .0003) and at the 7 mg dose (HR, 0.686; 95% CI, 0.540-0.871; = .0020). 

Zivadinov spoke with MD Magazine about TOPIC's key takeaways.


Robert Zivadinov, MD: 
If you asked me, “Can community neurologists assess the cortical atrophy in the way we did in this clinical trial?” The simple answer is no. Because you really need a high-quality MRI and you need the high-quality analysis to produce this data.

But, what community and academic neurologists should take away as a take-home message from this study is that they should not rely just on the lesion development to lead to the clinically definite MS, but they should think that, even in those people who do not have lesions and develop new lesions, they can develop substantial neurodegeneration in the cortex. As a matter of fact, sub-analysis of this study showed that cortical atrophy developed even in those patients who did not have Gd+ enhancing lesions at baseline. So they didn't have inflammatory activity.

I would say there are 2 messages that should be for the neurologists themselves. First, that the cortical pathology is not a late-stage phenomenon of the disease, it's a very early stage phenomenon, and it’s, in a very short period of 4 years, influencing clinical outcomes like this development of multiple sclerosis. So they have to take it into account. Second, that we have disease-modifying treatments, like Aubagio, which already showed us that from the early stage of the disease we can delay this process. I think by delaying this process, probably, we can delay long-term disability.

This is certainly yet to be shown, but I would suspect that this would be one of the reasons why, in a number of studies and other phase 3 trials like TEMSO, Aubagio showed the ability to delay disability progression in patients with MS. Whether this has an effect on cognition, is also yet to be shown, but just to give you an idea, cortical atrophy in all studies that have been done throughout the years, is the best predictor of cognitive disability in patients with MS.

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